What is the recommended dose of Yohimbine?

- **Fat loss:** 0.2mg/kg body weight (14mg for 70kg person), fasted, pre-exercise - **Erectile dysfunction:** 5.4-10mg 3x/day (prescription yohimbine HCl) - **Must be taken FASTED** — insulin compl...

Is Yohimbine safe to take daily?

Yohimbine is rated "Prescription Interactions" based on clinical evidence. - Anxiety, panic attacks (yohimbine is USED to induce panic in research) - Tachycardia (increased heart rate) - Hypertension (increased blood pressure) - Tremor, sweating, flushing - Nausea, GI distress - Insomnia - At high d

Does Yohimbine interact with any medications?

Yohimbine has 7 known drug interactions, including interactions with Stimulants (Adderall, caffeine, ephedrine), Blood pressure medications, SSRIs / antidepressants. Check with your doctor before combining with prescription medications.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Yohimbine

MODERATE EVIDENCESupplementLast updated April 2026

AVELOR SUMMARY

Yohimbine is an alpha-2 adrenergic antagonist derived from the bark of the Pausinystalia yohimbe tree. Our research shows it's the only supplement with direct mechanistic evidence for stubborn fat mobilization — it blocks the alpha-2 receptors that prevent lipolysis in problem areas (lower abdomen, thighs). However, it's also one of the most dangerous supplements available: it reliably increases heart rate, blood pressure, and anxiety, and has caused documented cases of cardiac arrhythmias and hypertensive crises.

EVIDENCE GRADES

Fat loss (specifically stubborn fat)Moderate — mechanism proven; clinical data limited (PMID: 17214405)

B-

Erectile dysfunctionModerate — pre-PDE5 inhibitor standard; still studied

B-

Exercise performanceLimited data

Blood pressure increaseConsistent, dose-dependent hypertension

⚠️ ADVERSE

Anxiety increaseUsed to INDUCE anxiety in panic disorder research

⚠️ ADVERSE

OPTIMAL DOSAGE

Fat loss: 0.2mg/kg body weight (14mg for 70kg person), fasted, pre-exercise
Erectile dysfunction: 5.4-10mg 3x/day (prescription yohimbine HCl)
Must be taken FASTED — insulin completely negates yohimbine's lipolytic effect
Start at 2.5-5mg to assess tolerance; increase gradually

Scan a supplement containing Yohimbine

DRUG INTERACTIONS

Stimulants (Adderall, caffeine, ephedrine)Severe

Additive sympathomimetic effects → hypertension, tachycardia, arrhythmia

Blood pressure medicationsSevere

Directly opposes antihypertensive effect (yohimbine RAISES BP)

SSRIs / antidepressantsSevere

Additive noradrenergic effects; may worsen anxiety/panic

MAO inhibitorsSevere

Hypertensive crisis risk — CONTRAINDICATED

Tricyclic antidepressantsSevere

Additive cardiovascular effects

ClonidineSevere

Directly opposes clonidine's alpha-2 agonism

NaltrexoneModerate

May enhance yohimbine's anxiogenic effects

SAFETY PROFILE

Drug Interactions

Side Effects

Anxiety, panic attacks (yohimbine is USED to induce panic in research)
Tachycardia (increased heart rate)
Hypertension (increased blood pressure)
Tremor, sweating, flushing
Nausea, GI distress
Insomnia
At high doses: piloerection, mydriasis, salivation

⚠️ CRITICAL SAFETY NOTE

Yohimbine bark extract (sold as "yohimbe") varies WILDLY in actual yohimbine content — testing found 0-12mg per capsule regardless of label claim (PMID: 26344461). Only pharmaceutical-grade yohimbine HCl allows reliable dosing. Yohimbe bark extract is essentially uncontrollable.

Pregnancy & Lactation

ABSOLUTELY CONTRAINDICATED — sympathomimetic effects, hypertension risk, insufficient safety data

WADA Status

Not Prohibited (but stimulant monitoring threshold applies)

WHO SHOULD BE CAREFUL

HOW AVELOR SCORES THIS

One of the highest-risk supplements in our databasecomparable to St. John's Wort for interaction severity

Yohimbine HCl (pharmaceutical grade): score as potent but manageable if properly dosed

Yohimbe bark extract: automatic severe quality concern flag (uncontrollable dosing)

ANY cardiovascular medication: automatic SEVERE interaction alert

ANY stimulant (including caffeine >200mg): automatic flag

Anxiety disorder in user profile: automatic contraindication

Products in "fat burner" blends with undisclosed yohimbine amounts: SEVERE flag

CLINICAL REFERENCES

Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players.

PMID: 17214405

Cohen PA et al. Yohimbe supplement labeling: How accurate is it? A study of yohimbe supplements.

PMID: 26344461

Charney DS et al. Yohimbine and human anxiety research.

PMID: 2900643

Riley AJ. Yohimbine in the treatment of erectile disorder.

PMID: 1987655

RELATED RESEARCH

Acacia Fiber

Activated Charcoal

Agave Inulin

Agmatine SulfateReduced neuropathic pain by 46.1%

Scan Your Yohimbine Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

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Browse All 834 Ingredients Browse All 20 Conditions

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Yohimbine

MODERATE EVIDENCESupplementLast updated April 2026

AVELOR SUMMARY

EVIDENCE GRADES

Fat loss (specifically stubborn fat)Moderate — mechanism proven; clinical data limited (PMID: 17214405)

B-

Erectile dysfunctionModerate — pre-PDE5 inhibitor standard; still studied

B-

Exercise performanceLimited data

Blood pressure increaseConsistent, dose-dependent hypertension

⚠️ ADVERSE

Anxiety increaseUsed to INDUCE anxiety in panic disorder research

⚠️ ADVERSE

OPTIMAL DOSAGE

Fat loss: 0.2mg/kg body weight (14mg for 70kg person), fasted, pre-exercise
Erectile dysfunction: 5.4-10mg 3x/day (prescription yohimbine HCl)
Must be taken FASTED — insulin completely negates yohimbine's lipolytic effect
Start at 2.5-5mg to assess tolerance; increase gradually

Scan a supplement containing Yohimbine

DRUG INTERACTIONS

Stimulants (Adderall, caffeine, ephedrine)Severe

Additive sympathomimetic effects → hypertension, tachycardia, arrhythmia

Blood pressure medicationsSevere

Directly opposes antihypertensive effect (yohimbine RAISES BP)

SSRIs / antidepressantsSevere

Additive noradrenergic effects; may worsen anxiety/panic

MAO inhibitorsSevere

Hypertensive crisis risk — CONTRAINDICATED

Tricyclic antidepressantsSevere

Additive cardiovascular effects

ClonidineSevere

Directly opposes clonidine's alpha-2 agonism

NaltrexoneModerate

May enhance yohimbine's anxiogenic effects

SAFETY PROFILE

Drug Interactions

Side Effects

Anxiety, panic attacks (yohimbine is USED to induce panic in research)
Tachycardia (increased heart rate)
Hypertension (increased blood pressure)
Tremor, sweating, flushing
Nausea, GI distress
Insomnia
At high doses: piloerection, mydriasis, salivation

⚠️ CRITICAL SAFETY NOTE

Pregnancy & Lactation

ABSOLUTELY CONTRAINDICATED — sympathomimetic effects, hypertension risk, insufficient safety data

WADA Status

Not Prohibited (but stimulant monitoring threshold applies)

WHO SHOULD BE CAREFUL

HOW AVELOR SCORES THIS

One of the highest-risk supplements in our databasecomparable to St. John's Wort for interaction severity

Yohimbine HCl (pharmaceutical grade): score as potent but manageable if properly dosed

Yohimbe bark extract: automatic severe quality concern flag (uncontrollable dosing)

ANY cardiovascular medication: automatic SEVERE interaction alert

ANY stimulant (including caffeine >200mg): automatic flag

Anxiety disorder in user profile: automatic contraindication

Products in "fat burner" blends with undisclosed yohimbine amounts: SEVERE flag

CLINICAL REFERENCES

Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players.

PMID: 17214405

Cohen PA et al. Yohimbe supplement labeling: How accurate is it? A study of yohimbe supplements.

PMID: 26344461

Charney DS et al. Yohimbine and human anxiety research.

PMID: 2900643

Riley AJ. Yohimbine in the treatment of erectile disorder.

PMID: 1987655

RELATED RESEARCH

Acacia Fiber

Activated Charcoal

Agave Inulin

Agmatine SulfateReduced neuropathic pain by 46.1%

Scan Your Yohimbine Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 834 Ingredients Browse All 20 Conditions