What is the recommended dose of Agmatine Sulfate?

- **Look for:** Agmatine sulfate, minimum 500mg per serving, third-party tested - **Avoid:** Products listing "agmatine" in a proprietary blend without specifying dose; products combining with high...

Is Agmatine Sulfate safe to take daily?

Agmatine Sulfate is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Agmatine Sulfate

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Agmatine is a metabolite of L-arginine that modulates multiple neurotransmitter systems (NMDA, imidazoline, alpha-2 adrenergic) and nitric oxide pathways. Preliminary human trials show it reduced neuropathic pain by 46% at doses of 1,330-3,560mg/day over 2 weeks. Our research identifies it as one of the most pharmacologically complex supplements available — its multi-receptor activity means drug interaction screening is essential.

WHAT IT DOES

Agmatine acts on at least four receptor systems simultaneously: it blocks NMDA glutamate receptors (reducing excitotoxicity and pain), activates imidazoline receptors (lowering blood pressure and modulating insulin), stimulates alpha-2 adrenergic receptors (pain modulation), and inhibits nitric oxide synthase (NOS) — but selectively. It inhibits iNOS (inflammatory NO) while preserving eNOS (vascular NO), which is why it can reduce inflammation without impairing blood flow.

OPTIMAL DOSAGE

Look for: Agmatine sulfate, minimum 500mg per serving, third-party tested
Avoid: Products listing "agmatine" in a proprietary blend without specifying dose; products combining with high-dose arginine
Minimum effective dose: 1,330mg/day for pain; 500-1,000mg for general use
Third-party tested brands: Nutricost, BulkSupplements (both offer standalone agmatine sulfate)

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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