Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD
White Willow Bark
MODERATE EVIDENCESupplementLast updated
AVELOR SUMMARY
White willow bark is the original aspirin — it contains salicin, which the body converts to salicylic acid (aspirin is acetylsalicylic acid). A 2001 Cochrane review found willow bark extract (240mg salicin/day) reduced low back pain by 39% — comparable to rofecoxib (Vioxx). Unlike aspirin, willow bark causes LESS GI irritation because salicin is converted to salicylic acid in the liver (not the stomach). Dose: 120-240mg salicin/day. Assalix® is the standardized extract. Same antiplatelet and drug interaction cautions as aspirin.
---
*Reviewed by the Dose AI Research Team and Clinical Advisory Board*
*Last updated: 2026-04-06*
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.