What is the recommended dose of TUDCA?

- **Liver protection:** 250-500mg/day - **Cholestatic liver disease:** 500-1,500mg/day (clinical doses) - **General ER stress support:** 250-500mg/day - Take with or without food — well absorbed ei...

Is TUDCA safe to take daily?

TUDCA is rated "Use Caution" based on clinical evidence. - Mild diarrhea at high doses (bile acid mechanism) - Generally very well tolerated - One of the safest liver-support supplements available

Does TUDCA interact with any medications?

TUDCA has 3 known drug interactions, including interactions with Cholestyramine / bile acid sequestrants, Aluminum-containing antacids, Cyclosporine. Check with your doctor before combining with prescription medications.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

TUDCA

STRONG EVIDENCESupplementLast updated April 2026

SCAN DOSE SUMMARY

TUDCA is a bile acid with potent hepatoprotective, neuroprotective, and endoplasmic reticulum stress-reducing properties. Our research shows strong evidence for cholestatic liver disease and growing evidence for general liver protection, including steroid-users and high-dose supplement consumers. It's become the go-to liver support supplement in the bodybuilding community for good reason — the mechanism is legitimate.

EVIDENCE GRADES

Cholestatic liver diseaseStrong — established medical use (PMID: 10446019)

Liver protection (general)Moderate — improves bile flow and liver enzymes

ER stress reductionStrong mechanistic + moderate clinical evidence

Neuroprotection (ALS, Alzheimer's)Preliminary — clinical trials ongoing

C+

Insulin sensitivityLimited human data

Retinal degenerationAnimal data promising

OPTIMAL DOSAGE

Liver protection: 250-500mg/day
Cholestatic liver disease: 500-1,500mg/day (clinical doses)
General ER stress support: 250-500mg/day
Take with or without food — well absorbed either way

Scan a supplement containing TUDCA

DRUG INTERACTIONS

Cholestyramine / bile acid sequestrantsModerate

Directly binds TUDCA, reducing absorption and efficacy

Aluminum-containing antacidsMinor

May reduce TUDCA absorption

CyclosporineModerate

TUDCA may alter cyclosporine absorption and enterohepatic cycling

SAFETY PROFILE

Drug Interactions

Side Effects

Mild diarrhea at high doses (bile acid mechanism)
Generally very well tolerated
One of the safest liver-support supplements available

Pregnancy & Lactation

UDCA (parent compound) is used clinically for intrahepatic cholestasis of pregnancy. TUDCA specifically lacks pregnancy data.

WADA Status

Not Prohibited

HOW SCAN DOSE SCORES THIS

Legitimate liver protection mechanism — score well for users on hepatotoxic supplements or medications

Products should specify TUDCA (not generic "bile acid" or UDCA)

Bodybuilder/athlete context: valid liver protection during oral steroid or high-dose supplement cycles

Bile acid sequestrant users: timing separation alert

"Liver detox" marketing: TUDCA has actual mechanism (unlike many "detox" products) — but reframe as "hepatoprotection" not "detox"

CLINICAL REFERENCES

Beuers U. Drug insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis.

PMID: 10446019

Ozcan U et al. Chemical chaperones reduce ER stress and restore glucose homeostasis.

PMID: 20427694

Elia AE et al. Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis.

PMID: 23906616

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

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