Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD
Strontium
MODERATE EVIDENCESupplementLast updated
AVELOR SUMMARY
Strontium ranelate (prescription, EU — Protelos®) reduced vertebral fractures by 41% and hip fractures by 36% in the SOTI/TROPOS trials. It's the only dual-action bone agent: stimulates osteoblasts (bone building) AND inhibits osteoclasts (bone resorption). BUT: cardiovascular safety concerns led to EU restrictions (increased MI/stroke risk). OTC strontium citrate has no cardiovascular data but also no fracture data. DEXA scans overestimate BMD by 8-12% in strontium users (strontium has higher atomic weight than calcium, creating artifact). Our assessment: prescription strontium ranelate has proven efficacy but CV risk. OTC strontium citrate is unproven.
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*Reviewed by the Dose AI Research Team and Clinical Advisory Board*
*Last updated: 2026-04-06*
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.