Is Propolis safe to take daily?

Propolis is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Propolis

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Propolis is the resinous antimicrobial sealant bees produce from tree sap + beeswax + enzymes. Contains 300+ compounds including CAPE (caffeic acid phenethyl ester), which inhibits NF-κB more potently than most pharmaceutical anti-inflammatories. Clinical evidence: propolis mouthwash reduced dental plaque by 44% and gingivitis by 36%. Brazilian green propolis (artepillin C-rich) reduced H. pylori infection when used as adjunct to triple therapy. Immunomodulatory — increased vaccine antibody response by 31% in elderly. Dose: 500-1,500mg/day extract. Allergy risk for bee-allergic individuals. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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