What is the recommended dose of Pregnenolone?

- **Look for:** Micronized pregnenolone, 10-30mg per capsule (conservative dose), third-party tested, physician supervision recommended - **Avoid:** High-dose products (100mg+) without medical guid...

Is Pregnenolone safe to take daily?

Pregnenolone is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

LOADINGLoading your Pro surface...

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Pregnenolone

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Pregnenolone is the "mother hormone" — the precursor from which ALL steroid hormones are synthesized (cortisol, DHEA, testosterone, estrogen, progesterone, aldosterone). Our research shows limited clinical evidence for supplementation benefits, despite its central role in hormone synthesis. The primary concern: exogenous pregnenolone can be converted into ANY downstream hormone, making its effects unpredictable. A small trial showed improved depressive symptoms and cognitive function in schizophrenia, but no large-scale trials exist for any indication. This is essentially self-administering a raw steroid precursor without knowing which hormones your body will make from it.

WHAT IT DOES

Pregnenolone sits at the top of the steroid hormone synthesis cascade. Cholesterol → pregnenolone (via CYP11A1/P450scc enzyme on mitochondrial inner membrane) → then it branches into THREE pathways: (1) mineralocorticoids (aldosterone — salt/water balance); (2) glucocorticoids (cortisol — stress response); (3) sex hormones (via DHEA → androstenedione → testosterone/estrogen; or via progesterone → cortisol). When you supplement pregnenolone, your body's enzymes direct it based on current needs, genetic enzyme expression, and hormonal feedback — making the outcome highly individual. Additionally, pregnenolone itself is a neurosteroid that modulates GABA-A receptors (enhancing or inhibiting depending on metabolites) and NMDA receptors.

OPTIMAL DOSAGE

Look for: Micronized pregnenolone, 10-30mg per capsule (conservative dose), third-party tested, physician supervision recommended
Avoid: High-dose products (100mg+) without medical guidance; combination "hormone optimization" stacks with multiple precursors; products marketed to children or young adults
Minimum effective dose: 10mg/day for neurosteroid effects; hormonal effects are unpredictable at any dose
Third-party tested brands: Life Extension, Pure Encapsulations

Scan a supplement containing Pregnenolone

SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

RELATED RESEARCH

Acacia Fiber

Activated Charcoal

Agave Inulin

Agmatine SulfateReduced neuropathic pain by 46.1%

Scan Your Pregnenolone Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 834 Ingredients Browse All 20 Conditions