Policosanol

Policosanol (from sugarcane wax) was reported by Cuban researchers to reduce LDL by 20-25% — rivaling statins. Then EVERY independent replication FAILED. A 2006 German study, a 2002 Dutch study, and a 2006 Canadian study ALL found zero cholesterol effect. Our assessment: the Cuban data is unreliable — likely publication bias or methodological issues specific to that one research group. Not recommended for cholesterol management despite continued marketing. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*