Is Perilla safe to take daily?

Perilla is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Perilla

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Perilla leaf extract contains rosmarinic acid and luteolin — potent mast cell stabilizers. A 2004 RCT found 50mg rosmarinic acid from perilla reduced allergic rhinitis symptoms significantly — reduced sneezing, nasal blockage, and itchy eyes by 50-70%. The mechanism: rosmarinic acid inhibits IgE-mediated mast cell degranulation AND blocks 5-LOX/COX-2 (dual anti-inflammatory). Japanese Kampo medicine uses perilla for allergies and asthma. Dose: 200-500mg/day perilla extract standardized to rosmarinic acid. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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