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Myo-inositol is a second messenger in the insulin signaling cascade. After insulin binds its receptor, a phospholipase cleaves phosphatidylinositol → inositol phosphoglycans (IPGs) → which activate downstream insulin signals (GLUT4 translocation, glycogen synthesis). In PCOS, this pathway is impaired — excess insulin is produced to compensate (hyperinsulinemia), which stimulates ovarian androgen production (testosterone, causing acne, hirsutism, anovulation). Supplemental myo-inositol restores insulin sensitivity → reduces compensatory hyperinsulinemia → reduces ovarian androgen production → restores ovulation. For anxiety: myo-inositol is the precursor to phosphatidylinositol, which is required for serotonin receptor (5-HT2) signaling — explaining the anti-anxiety effect at high doses.
No critical interactions identified.
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.