What is the recommended dose of Indole-3-Carbinol?

- **Look for:** DIM is preferred over I3C; if I3C: 200-400mg per serving; or DIM 100-200mg with BioPerine for absorption - **Avoid:** I3C alone at very high doses (AhR activation concern from ICZ);...

Is Indole-3-Carbinol safe to take daily?

Indole-3-Carbinol is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Indole-3-Carbinol

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

I3C is released when you chew cruciferous vegetables (broccoli, cauliflower, Brussels sprouts). In the stomach, it converts to DIM (3,3'-diindolylmethane) and other condensation products. Our research shows I3C/DIM modulates estrogen metabolism — shifting the ratio from 16α-hydroxyestrone (growth-promoting, cancer-associated) to 2-hydroxyestrone (protective). This estrogen metabolism shift has moderate evidence for cervical dysplasia (HPV-related), breast cancer risk reduction, and estrogen dominance symptoms. We already have a DIM file — I3C is the precursor that converts to DIM in the stomach.

WHAT IT DOES

In the acidic environment of the stomach, I3C undergoes acid-catalyzed condensation to form DIM (~10-20% of I3C converts), ICZ (indolo[3,2-b]carbazole — a potent AhR agonist), and other condensation products. DIM modulates estrogen metabolism by: (1) inducing CYP1A1/1A2 (Phase I enzymes that produce protective 2-OHE1) and suppressing CYP1B1 (which produces genotoxic 4-OHE1); (2) acting as an androgen receptor antagonist at high concentrations; (3) inhibiting NF-κB. The concern: ICZ is a potent aryl hydrocarbon receptor (AhR) agonist — the same receptor activated by dioxin — raising theoretical long-term safety questions that DIM supplementation avoids.

OPTIMAL DOSAGE

Look for: DIM is preferred over I3C; if I3C: 200-400mg per serving; or DIM 100-200mg with BioPerine for absorption
Avoid: I3C alone at very high doses (AhR activation concern from ICZ); combination "estrogen detox" blends with undisclosed amounts
Minimum effective dose: 200mg I3C or 100mg DIM
Third-party tested brands: NOW Foods (DIM), Life Extension, Smoky Mountain Naturals

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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