GABA (Oral Supplement) — Extended

for primary monograph. Oral GABA's ability to cross the blood-brain barrier is highly debated — most neuroscientists believe it does NOT cross in significant amounts. Pharma-GABA (natural GABA from Lactobacillus hilgardii fermentation) showed EEG changes suggesting SOME BBB penetration at 100mg. The peripheral effects (relaxation, growth hormone release) may be mediated by enteric nervous system GABA receptors in the gut. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*