What is the recommended dose of Fisetin?

- **Look for:** Liposomal fisetin or Novusetin® for enhanced bioavailability; minimum 100mg per capsule; taken with fat source - **Avoid:** Standard fisetin powder without bioavailability solution ...

Is Fisetin safe to take daily?

Fisetin is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Fisetin

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Fisetin is a flavonoid found in strawberries and is the most potent natural senolytic compound identified — clearing senescent ("zombie") cells that accumulate with aging and drive chronic inflammation. A 2018 study in Nature Medicine found fisetin extended median lifespan in aged mice by 10%. The Mayo Clinic is running active clinical trials in humans. Our research flags that bioavailability is extremely poor (oral absorption <5%), making dose form critical — and the human evidence base, while exciting, consists mainly of ongoing trials, not published results.

WHAT IT DOES

Senescent cells are damaged cells that stop dividing but refuse to die — they accumulate with age and pump out inflammatory cytokines (the SASP — senescence-associated secretory phenotype) that damage surrounding tissue and drive chronic inflammation, tissue deterioration, and age-related disease. Fisetin triggers apoptosis (programmed cell death) specifically in these senescent cells while leaving healthy cells unaffected. It does this by inhibiting the PI3K/AKT/mTOR survival pathway that senescent cells depend on. It also activates SIRT1, reduces NF-κB-driven inflammation, and has direct antioxidant activity.

OPTIMAL DOSAGE

Look for: Liposomal fisetin or Novusetin® for enhanced bioavailability; minimum 100mg per capsule; taken with fat source
Avoid: Standard fisetin powder without bioavailability solution (wasting money at <5% absorption); products making bold longevity claims without disclosing the research is primarily preclinical
Minimum effective dose: 100mg/day (bioavailability-enhanced form); standard form may need 500mg+
Third-party tested brands: Doctor's Best (Novusetin), Renue By Science (liposomal)

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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