What is the recommended dose of Fadogia Agrestis?

- **Look for:** Third-party tested for heavy metals and adulterants (minimum requirement for any herbal from sub-Saharan Africa) - **Avoid:** ALL products without third-party testing; products maki...

Is Fadogia Agrestis safe to take daily?

Fadogia Agrestis is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Fadogia Agrestis

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Fadogia agrestis is a Nigerian shrub that gained massive popularity after Andrew Huberman recommended it alongside tongkat ali for testosterone support. Our research reveals a concerning reality: there is exactly ONE animal study showing testosterone increase — in rats, at doses equivalent to 18-100mg/kg — and that SAME study found dose-dependent testicular toxicity (testicular cell damage) at the effective doses. There are ZERO human clinical trials. This is one of the highest-risk supplements in our database due to the combination of organ toxicity signal and complete absence of human safety data.

WHAT IT DOES

The proposed mechanism (from the single rat study) is that fadogia's alkaloids and saponins stimulate Leydig cells to produce more testosterone — similar to how LH works. However, the same stimulation appears to damage those cells at effective doses. It's essentially overstimulating the testosterone-producing machinery until it breaks. The alkaloids involved have not been fully characterized, the dose-response curve in humans is completely unknown, and there is no safety margin established.

OPTIMAL DOSAGE

Look for: Third-party tested for heavy metals and adulterants (minimum requirement for any herbal from sub-Saharan Africa)
Avoid: ALL products without third-party testing; products making testosterone claims without disclosing the testicular toxicity signal; combination "testosterone stacks" hiding fadogia dose
Minimum effective dose: Unknown — no human dose-finding studies exist
Third-party tested brands: No brands have been validated for fadogia specifically. Nootropics Depot conducts some testing but cannot verify efficacy.

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

Insufficient data to classify any interaction as "low-risk" — ALL interactions are unknown.

WHO SHOULD BE CAREFUL

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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