What is the recommended dose of DIM?

- **Look for:** BioResponse DIM (microencapsulated for absorption), 100-200mg per serving, third-party tested - **Avoid:** Crystalline DIM without bioavailability enhancement; doses >300mg (estroge...

Is DIM safe to take daily?

DIM is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

DIM

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

DIM is a metabolite of indole-3-carbinol (I3C) found in cruciferous vegetables that modulates estrogen metabolism — specifically shifting the 2:16 hydroxyestrone ratio toward the less proliferative 2-OH metabolite. Our research shows a 50% increase in the 2:16 ratio at 108mg/day, which has theoretical implications for estrogen-dependent cancer prevention. However, DIM is NOT simply an "estrogen blocker" as commonly marketed — at high doses it can actually have estrogenic effects.

WHAT IT DOES

When you eat broccoli, stomach acid converts glucosinolates to I3C, which then polymerizes into DIM. DIM modulates estrogen metabolism by inducing CYP1A1 enzyme, which shifts estrogen breakdown toward 2-hydroxyestrone (considered protective) and away from 16α-hydroxyestrone (associated with proliferative/cancer-promoting activity). DIM also acts on the aryl hydrocarbon receptor (AhR), which has broader effects on detoxification, immune function, and cellular proliferation. The biphasic dose response is critical: at low-moderate doses it's anti-estrogenic; at high doses it becomes estrogenic.

OPTIMAL DOSAGE

Look for: BioResponse DIM (microencapsulated for absorption), 100-200mg per serving, third-party tested
Avoid: Crystalline DIM without bioavailability enhancement; doses >300mg (estrogenic crossover); I3C instead of DIM (less predictable)
Minimum effective dose: 100mg/day BioResponse DIM
Third-party tested brands: Smoky Mountain Nutrition (BioResponse DIM), Nature's Way (DIM-plus)

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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