What is the recommended dose of D-Aspartic Acid?

- **Most studied:** 2,000-3,000mg/day (sodium D-aspartate form) - **Fertility applications:** 2,660mg/day for 90 days - **Cycle:** Most protocols suggest 2-3 weeks on, 1-2 weeks off

Is D-Aspartic Acid safe to take daily?

D-Aspartic Acid is rated "Generally Safe" based on clinical evidence. - Irritability and mood changes (anecdotal) - Headache (uncommon) - GI discomfort

Does D-Aspartic Acid interact with any medications?

D-Aspartic Acid has 1 known drug interaction, including interactions with Testosterone replacement therapy. Check with your doctor before combining with prescription medications.

LOADINGLoading your Pro surface...

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

D-Aspartic Acid

LIMITED EVIDENCESupplementLast updated April 2026

SCAN DOSE SUMMARY

D-Aspartic acid was briefly hyped as a natural testosterone booster — our research shows the initial positive study has NOT been replicated in young, healthy men. One trial showed 15% testosterone increase over 12 days in untrained men, but subsequent trials in resistance-trained men found no effect or even slight decreases. The evidence does not support DAA for testosterone boosting in athletic populations.

EVIDENCE GRADES

Testosterone increase (untrained/older men)One positive trial, not replicated (PMID: 19860889)

Testosterone (resistance-trained men)Null or negative results (PMID: 24074027)

Male fertility (sperm quality)More promising — improved sperm parameters

C+

Luteinizing hormoneAcute increase, uncertain chronic effect

OPTIMAL DOSAGE

Most studied: 2,000-3,000mg/day (sodium D-aspartate form)
Fertility applications: 2,660mg/day for 90 days
Cycle: Most protocols suggest 2-3 weeks on, 1-2 weeks off

Scan a supplement containing D-Aspartic Acid

DRUG INTERACTIONS

Testosterone replacement therapyMinor

May have additive effects on LH/FSH axis; clinically irrelevant if on exogenous T

SAFETY PROFILE

Drug Interactions

Side Effects

Irritability and mood changes (anecdotal)
Headache (uncommon)
GI discomfort

WADA Status

Not Prohibited (but testosterone itself is — if DAA raised testosterone beyond natural range, it could theoretically cause a failed test)

HOW SCAN DOSE SCORES THIS

Products marketed as "testosterone boosters" with DAA as primary ingredient: flag — evidence does not support this claim in trained men

Fertility applications: more evidence; score accordingly

Any "test booster" proprietary blend: automatic flag

CLINICAL REFERENCES

Topo E et al. The role and molecular mechanism of D-aspartic acid in the release of LH and testosterone.

PMID: 19860889

Willoughby DS, Leutholtz B. D-Aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition.

PMID: 24074027

RELATED RESEARCH

Acacia Fiber

Activated Charcoal

Agave Inulin

Agmatine SulfateReduced neuropathic pain by 46.1%

Scan Your D-Aspartic Acid Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 834 Ingredients Browse All 20 Conditions