What is the recommended dose of Cinnamon?

- **Blood sugar support:** 1-6g/day (cassia) or equivalent extract - **Extract (10:1 concentration):** 120-500mg/day - **Cinnulin PF (branded extract):** 250-500mg/day - **CRITICAL: Choose Ceylon c...

Is Cinnamon safe to take daily?

Cinnamon is rated "Use Caution" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Does Cinnamon interact with any medications?

Cinnamon has 4 known drug interactions, including interactions with Diabetes medications (metformin, insulin), Warfarin, Hepatotoxic drugs. Check with your doctor before combining with prescription medications.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Cinnamon

MODERATE EVIDENCESupplementLast updated April 2026

AVELOR SUMMARY

Cinnamon (Cinnamomum cassia and Cinnamomum verum/Ceylon) has moderate evidence for modest blood sugar reduction in type 2 diabetes — roughly 10-25 mg/dL fasting glucose reduction. Our research distinguishes between cassia (common, contains coumarin — liver toxic at high doses) and Ceylon (safer, less studied). The blood sugar effect is real but small and won't replace medication.

EVIDENCE GRADES

Fasting blood glucoseModerate — meta-analyses confirm modest effect (PMID: 22854650)

B-

HbA1cInconsistent across trials

C+

Lipid profile (LDL, triglycerides)Modest reductions in some trials

C+

Insulin sensitivityPreliminary

PCOS metabolic markersLimited trials

OPTIMAL DOSAGE

Blood sugar support: 1-6g/day (cassia) or equivalent extract
Extract (10:1 concentration): 120-500mg/day
Cinnulin PF (branded extract): 250-500mg/day
CRITICAL: Choose Ceylon cinnamon for doses >1g/day — cassia contains 1-10mg coumarin per gram; TDI for coumarin is 0.1mg/kg body weight

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DRUG INTERACTIONS

Diabetes medications (metformin, insulin)Moderate

Additive blood sugar lowering

WarfarinModerate

Cassia cinnamon contains coumarin compounds; may interact

Hepatotoxic drugsModerate

Coumarin in cassia is hepatotoxic at high doses; additive liver stress

CYP2A6 substratesMinor

Coumarin is metabolized via CYP2A6; competition possible

SAFETY PROFILE

Drug Interactions

⚠️ Coumarin Toxicity (Cassia vs Ceylon)

Cassia cinnamon (most common type sold) contains 1-10mg coumarin per gram. The European Food Safety Authority tolerable daily intake is 0.1mg/kg. For a 70kg adult, that's 7mg — easily exceeded with 2-3g of cassia cinnamon daily. Chronic coumarin exposure causes hepatotoxicity (PMID: 20024932). Ceylon (true) cinnamon contains negligible coumarin (<0.01mg/g) and is safe at higher doses.

Pregnancy & Lactation

Culinary amounts safe. Avoid supplemental doses — cassia coumarin may be teratogenic at high doses.

WADA Status

Not Prohibited

HOW AVELOR SCORES THIS

Ceylon cinnamon products score higher than cassia for long-term use (coumarin safety)

Products not specifying species (cassia vs Ceylon): flag as potential coumarin risk

Diabetes medication users: automatic interaction flag

Products >2g/day cassia: liver toxicity warning

Cinnulin PF: branded extract with removal of coumarin — scores well

CLINICAL REFERENCES

Allen RW et al. Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis.

PMID: 22854650

Abraham K et al. Toxicology and risk assessment of coumarin.

PMID: 20024932

Khan A et al. Cinnamon improves glucose and lipids in people with type 2 diabetes.

PMID: 16634838

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

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