What is the recommended dose of Butyrate / Butyric Acid?

- **Look for:** Tributyrin (ProButyrate® — best delivery to colon); sodium butyrate; calcium/magnesium butyrate; enteric-coated or delayed-release; 300-600mg per serving - **Avoid:** Plain butyric ...

Is Butyrate / Butyric Acid safe to take daily?

Butyrate / Butyric Acid is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Butyrate / Butyric Acid

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Butyrate is the most important short-chain fatty acid (SCFA) for gut health — it's the PRIMARY energy source for colonocytes (cells lining your colon get 70% of their energy from butyrate, not glucose). Your gut bacteria produce it by fermenting dietary fiber. Our research shows butyrate has profound effects: it maintains intestinal barrier integrity (prevents "leaky gut"), has anti-cancer effects in colorectal tissue (paradoxically — it feeds normal colonocytes but kills cancer cells via the "butyrate paradox"), reduces inflammation via HDAC inhibition, and has emerging evidence for brain function via the gut-brain axis. Supplemental butyrate (as sodium/calcium butyrate or tributyrin) can bypass the need for fiber fermentation.

WHAT IT DOES

Butyrate's mechanisms: (1) Colonocyte fuel — enters mitochondria via β-oxidation, providing 70% of colonocyte ATP (healthy colonocytes preferentially use butyrate over glucose); (2) HDAC inhibition — butyrate is a class I/II histone deacetylase inhibitor, altering gene expression toward anti-inflammatory, anti-proliferative, and pro-apoptotic programs (this is the anti-cancer mechanism); (3) GPR41/GPR43/GPR109A receptor activation — these SCFA receptors on immune cells, enteroendocrine cells, and neurons mediate immune tolerance (Treg induction), GLP-1/PYY secretion (satiety), and gut-brain signaling; (4) tight junction protein upregulation — increases expression of claudins and occludin, strengthening the intestinal barrier; (5) mucosal blood flow increase — vasodilatory effects in colonic vasculature.

OPTIMAL DOSAGE

Look for: Tributyrin (ProButyrate® — best delivery to colon); sodium butyrate; calcium/magnesium butyrate; enteric-coated or delayed-release; 300-600mg per serving
Avoid: Plain butyric acid liquid (rancid smell, gastric irritation); products without delayed-release (butyrate absorbed in small intestine before reaching colon)
Minimum effective dose: 300mg 2x/day supplemental butyrate
Third-party tested brands: BodyBio (sodium butyrate), Designs for Health (Tributyrate-X), NOW Foods

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

No critical interactions identified.

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

WHO SHOULD BE CAREFUL

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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