What is the recommended dose of BioPerine® / Piperine?

- **Look for:** BioPerine® brand (Sabinsa); standardized to 95% piperine; 5-10mg per serving - **Avoid:** Non-standardized "black pepper"; products with >20mg piperine (unnecessary and increases dr...

Is BioPerine® / Piperine safe to take daily?

BioPerine® / Piperine is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

LOADINGLoading your Pro surface...

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

BioPerine® / Piperine

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Piperine is the bioavailability enhancer found in black pepper — it increases the absorption of dozens of nutrients and drugs by inhibiting intestinal and hepatic CYP3A4 and P-glycoprotein. The famous example: piperine increases curcumin bioavailability by 2,000%. BioPerine® (Sabinsa) is the patented standardized extract (95% piperine) used in most combination supplements. Our research shows piperine genuinely enhances absorption, but this SAME mechanism means it can increase drug levels — it's essentially a pharmacokinetic modifier that affects anything metabolized by CYP3A4, which includes ~50% of all prescription drugs.

WHAT IT DOES

Piperine enhances bioavailability through: (1) CYP3A4 inhibition — blocks the liver enzyme responsible for metabolizing ~50% of all drugs and many supplements, reducing first-pass metabolism; (2) P-glycoprotein inhibition — P-gp is an efflux pump in intestinal cells that pushes absorbed compounds back into the gut lumen. Blocking it increases net absorption; (3) UDP-glucuronosyltransferase (UGT) inhibition — blocks glucuronidation (the process that inactivates curcumin, resveratrol, and other polyphenols); (4) increased intestinal blood flow — improves absorption rate. The net effect: more of the co-ingested compound reaches systemic circulation.

OPTIMAL DOSAGE

Look for: BioPerine® brand (Sabinsa); standardized to 95% piperine; 5-10mg per serving
Avoid: Non-standardized "black pepper"; products with >20mg piperine (unnecessary and increases drug interaction risk)
Minimum effective dose: 5mg piperine
Third-party tested brands: BioPerine (Sabinsa — patent holder), Doctor's Best, NOW Foods

Scan a supplement containing BioPerine® / Piperine

SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

RELATED RESEARCH

Acacia Fiber

Activated Charcoal

Agave Inulin

Agmatine SulfateReduced neuropathic pain by 46.1%

Scan Your BioPerine® / Piperine Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 834 Ingredients Browse All 20 Conditions