What is the recommended dose of Baicalein / Baicalin?

- **Look for:** Scutellaria baicalensis (NOT lateriflora); standardized to baicalein and/or baicalin content; root extract - **Avoid:** American skullcap (S. lateriflora); products not specifying s...

Is Baicalein / Baicalin safe to take daily?

Baicalein / Baicalin is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Baicalein / Baicalin

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Baicalein is a flavonoid from Chinese Skullcap (Scutellaria baicalensis — NOT American skullcap, which is a different plant). Our research shows baicalein is one of the most potent natural 12-LOX and 15-LOX inhibitors known — blocking inflammatory pathways that COX inhibitors (aspirin, ibuprofen) miss entirely. It also has strong anxiolytic effects through GABA-A receptor modulation at the benzodiazepine site, inhibits neuroinflammation via TLR4/NF-κB, and has emerging evidence for neuroprotection in Parkinson's (prevents α-synuclein aggregation). The Japanese approved Kampo formulations containing baicalin for inflammatory conditions.

WHAT IT DOES

Baicalein/baicalin work through: (1) 12/15-LOX inhibition — blocks lipoxygenase enzymes that produce leukotrienes (LTB4, LTC4) and lipoxins. These are inflammatory mediators that NSAIDs don't touch, explaining why baicalein works on inflammation resistant to COX inhibitors; (2) GABA-A positive allosteric modulation — binds the benzodiazepine site on GABA-A receptors, enhancing GABA signaling for anxiolytic effect without sedation or dependence; (3) α-synuclein aggregation inhibition — binds to and stabilizes α-synuclein monomers, preventing the toxic oligomerization that drives Parkinson's; (4) NF-κB inhibition via IKK and TLR4 pathway suppression. Baicalein (aglycone) is better absorbed than baicalin (glycoside), but gut bacteria convert baicalin→baicalein anyway.

OPTIMAL DOSAGE

Look for: Scutellaria baicalensis (NOT lateriflora); standardized to baicalein and/or baicalin content; root extract
Avoid: American skullcap (S. lateriflora); products not specifying species; hepatotoxicity reports linked to S. lateriflora contamination
Minimum effective dose: 250mg baicalin; or 100mg baicalein
Third-party tested brands: Nootropics Depot, Life Extension, Thorne

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

WHO SHOULD BE CAREFUL

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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