LOADINGLoading your Pro surface...
Artichoke leaf contains cynarin (dicaffeoylquinic acid) and chlorogenic acid that: (1) stimulate bile acid synthesis and secretion from hepatocytes (choleretic effect) — more bile = better fat emulsification and digestion; (2) activate AMPK in the liver — increasing fatty acid β-oxidation and reducing cholesterol synthesis (mild statin-like + metformin-like effect); (3) inhibit HMG-CoA reductase — direct cholesterol synthesis reduction; (4) provide potent antioxidant activity — protecting hepatocytes from oxidative damage (cynaropicrin and luteolin). The IBS improvement is attributed to improved fat digestion (many IBS patients have bile acid malabsorption as a contributing factor).
No critical interactions identified.
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.