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ARA is released from cell membrane phospholipids by phospholipase A2 during mechanical stress (exercise). Once freed, COX-2 converts ARA to PGF2α and PGE2. PGF2α activates FP receptors on muscle cells → calcium-dependent signaling → muscle protein synthesis (mTOR-independent pathway). This is the LOCAL inflammatory response that drives muscle adaptation. The concern about systemic inflammation is largely unfounded in exercising individuals because the prostaglandins are produced locally, act in paracrine fashion, and are rapidly metabolized. The key insight: NSAIDs blunt this pathway, which is why chronic NSAID use reduces muscle gains.
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.