Andrographis

WHAT IT DOES

Andrographolides work through: (1) NF-κB covalent inhibition — andrographolide forms a Michael adduct with the p50 DNA-binding domain of NF-κB, blocking inflammatory gene transcription; (2) enhanced immune cell function — increased phagocytic activity and antibody production (IgG, IgM); (3) antiviral — inhibits viral RNA-dependent RNA polymerase and blocks viral entry; (4) hepatoprotective — increases glutathione and SOD activity, protecting liver from oxidative damage. The anti-inflammatory mechanism (covalent NF-κB binding) is pharmacologically unique — most anti-inflammatory compounds use reversible binding.

OPTIMAL DOSAGE

SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions