Is Vitamin B2 safe to take daily?

Vitamin B2 is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Vitamin B2

MODERATE EVIDENCEVitaminLast updated

AVELOR SUMMARY

Riboflavin is essential for FAD/FMN coenzymes. HIGH-DOSE riboflavin (400mg/day) reduced migraine frequency by 59% in a landmark RCT — one of the best-evidenced migraine preventives. Also: required for MTHFR enzyme function (riboflavin deficiency worsens homocysteine in MTHFR mutants), and essential for glutathione reductase (regenerating reduced glutathione). Bright yellow urine from riboflavin is harmless. RDA: 1.1-1.3mg/day. Therapeutic: 400mg/day for migraine. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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