Is Sulbutiamine safe to take daily?

Sulbutiamine is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Sulbutiamine

MODERATE EVIDENCEVitaminLast updated

AVELOR SUMMARY

Sulbutiamine is a synthetic lipophilic dimer of thiamine (vitamin B1) that crosses the BBB more efficiently than regular thiamine. Developed in Japan for asthenia (chronic fatigue). A 2003 study found 400mg/day reduced fatigue in post-infectious asthenia. Also increases thiamine triphosphate in brain — a neuromodulator distinct from regular thiamine pyrophosphate (the coenzyme form). Used in nootropic stacks for focus and mood. Tolerance develops within 10 days — cycle 5 days on / 2 days off. Dose: 200-600mg/day. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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