What is the recommended dose of Tongkat Ali?

- **Look for:** LJ100® / Physta® (standardized hot-water extract — most clinical data); standardized to eurypeptides (22%) + glycosaponins (40%); heavy metal tested; 200-400mg per serving - **Avoid...

Is Tongkat Ali safe to take daily?

Tongkat Ali is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Tongkat Ali

MODERATE EVIDENCEBotanicalLast updated

SCAN DOSE SUMMARY

Tongkat Ali is one of the few "testosterone boosters" with genuine clinical evidence — but through an UNUSUAL mechanism. Instead of directly stimulating testosterone synthesis, it reduces cortisol (by up to 16%) and SHBG binding, which FREES existing testosterone. A 2013 RCT found 200mg/day improved testosterone profile (37% increase in total testosterone vs cortisol reduction) and stress hormones in moderately stressed adults. The Malaysian government invested heavily in Eurycoma research (it's their national herb), producing more clinical data than most testosterone-related botanicals. LJ100® (Physta) is the standardized extract with the most trials.

WHAT IT DOES

Eurypeptides and quassinoids (eurycomanone) from Eurycoma longifolia work through: (1) HPA axis modulation — reduces cortisol release from adrenal glands, which reduces cortisol's suppressive effect on the HPG axis (high cortisol suppresses LH and testosterone); (2) SHBG reduction — increases free testosterone percentage without increasing total testosterone (some studies show total T increase, others just improved free:total ratio); (3) phosphodiesterase inhibition (mild) — increases cAMP in Leydig cells (minor direct testosterone support); (4) aromatase inhibition (mild) — reduces testosterone → estrogen conversion. The cortisol mechanism is key: this is fundamentally an anti-stress/adaptogenic testosterone support, NOT a direct anabolic.

OPTIMAL DOSAGE

Look for: LJ100® / Physta® (standardized hot-water extract — most clinical data); standardized to eurypeptides (22%) + glycosaponins (40%); heavy metal tested; 200-400mg per serving
Avoid: Non-standardized root powder; Malaysian/Indonesian products without heavy metal certification; "testosterone booster" blends with undisclosed amounts; alcohol extracts (different compound profile)
Minimum effective dose: 200mg/day LJ100/Physta
Third-party tested brands: Nootropics Depot (LJ100), DGS (Physta), Thorne

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

No critical interactions identified.

Moderate Interactions (Monitor Closely)

WHO SHOULD BE CAREFUL

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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