What is the recommended dose of Quercetin?

- **Look for:** Quercefit® (phytosomal — 20x absorption); or quercetin dihydrate + vitamin C + bromelain; dose ≥500mg standard or ≥250mg phytosomal - **Avoid:** Standard quercetin powder without ab...

Is Quercetin safe to take daily?

Quercetin is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Quercetin

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Quercetin is the most abundant dietary flavonoid — found in onions, apples, berries, and green tea — and is emerging as a potential senolytic (kills senescent "zombie" cells). The Mayo Clinic's landmark senolytic protocol combines quercetin (1,000mg) + dasatinib to clear senescent cells in humans. Our research shows quercetin also has strong anti-allergy effects (mast cell stabilization), modest endurance performance improvement (2.9% in a meta-analysis), and significant antiviral activity (reduced COVID illness duration by 70% in one RCT). The main limitation is poor bioavailability (~2% without enhancement) — phytosomal and liposomal forms address this.

WHAT IT DOES

Quercetin works through multiple mechanisms: (1) mast cell stabilization — inhibits degranulation and histamine release (anti-allergy, superior to cromolyn sodium in vitro); (2) NF-κB inhibition — broad anti-inflammatory effect; (3) senolytic activity — selectively induces apoptosis in senescent cells by inhibiting pro-survival pathways (BCL-2 family, PI3K/Akt, HIF-1α) that zombie cells depend on; (4) antiviral — inhibits viral entry (3CLpro protease inhibitor for coronaviruses, neuraminidase inhibitor for influenza); (5) eNOS activation — increases NO for vasodilation (blood pressure reduction). The poor bioavailability (2%) is due to rapid phase II metabolism (glucuronidation/sulfation in liver and intestine). Phytosomal formulation wraps quercetin in phospholipid, increasing absorption 20x.

OPTIMAL DOSAGE

Look for: Quercefit® (phytosomal — 20x absorption); or quercetin dihydrate + vitamin C + bromelain; dose ≥500mg standard or ≥250mg phytosomal
Avoid: Standard quercetin powder without absorption enhancers (only 2% bioavailable); products <200mg without phytosomal technology
Minimum effective dose: 500mg standard; 250mg phytosomal
Third-party tested brands: Thorne (Quercetin Phytosome), NOW Foods (Quercetin with Bromelain), Life Extension

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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