What is the recommended dose of Passionflower?

- **Look for:** Passiflora incarnata aerial parts (leaf + stem + flower); standardized to 3.5% flavonoids or vitexin content specified; 400-800mg per serving - **Avoid:** Products using Passiflora ...

Is Passionflower safe to take daily?

Passionflower is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Passionflower

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Passionflower is a GABAergic anxiolytic herb with one remarkable finding: a double-blind RCT found it was equivalent to oxazepam (a benzodiazepine) for generalized anxiety disorder, with faster onset and fewer side effects (specifically less job performance impairment). Our research shows it works through GABA-A modulation — the same receptor family as benzodiazepines — but with a gentler profile. EMA (European Medicines Agency) approved it as a traditional herbal medicine for mild anxiety and sleep disturbance.

WHAT IT DOES

Passionflower contains multiple GABA-active compounds: chrysin is a partial agonist at the benzodiazepine binding site on GABA-A receptors (the same site where Xanax and Valium bind, but as a partial agonist — weaker, safer). Other flavonoids (vitexin, isovitexin) and the GABA amino acid found in the plant also contribute to anxiolytic effects. Unlike benzodiazepines, passionflower does not produce significant tolerance, dependence, amnesia, or psychomotor impairment at standard doses — making it one of the safer natural anxiolytics available.

OPTIMAL DOSAGE

Look for: Passiflora incarnata aerial parts (leaf + stem + flower); standardized to 3.5% flavonoids or vitexin content specified; 400-800mg per serving
Avoid: Products using Passiflora edulis (passion fruit — different species, not studied for anxiety); fruit preparations; unstandardized products
Minimum effective dose: 400mg extract/day or 2g dried herb in tea
Third-party tested brands: NOW Foods, Nature's Way (Passiflora), Gaia Herbs

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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