What is the recommended dose of Mastic Gum?

- **Look for:** "Chios mastic gum" or PDO-certified origin; whole resin tears or powder; 500-1,000mg per serving - **Avoid:** Non-Chios origin mastic; products not specifying geographic origin; ver...

Is Mastic Gum safe to take daily?

Mastic Gum is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Mastic Gum

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Mastic gum is a resin from the mastic tree unique to the Greek island of Chios, with a documented 2,500-year history of GI use. Our research shows it has genuine anti-H. pylori activity (cleared H. pylori in 30% of patients as monotherapy — remarkable for a plant extract) and significant evidence for functional dyspepsia (indigestion) symptom improvement. The EU granted Chios mastic gum PDO (Protected Designation of Origin) status. A 2010 RCT found 350mg 3x/day significantly reduced dyspepsia symptoms by 40%. It also has anti-inflammatory and lipid-lowering properties. The key limitation: mastic gum from Chios is relatively expensive and only the Chios variety has clinical evidence.

WHAT IT DOES

Mastic gum's triterpenic acids work through: (1) H. pylori inhibition — masticadienonic acid inhibits H. pylori urease (the enzyme bacteria use to survive gastric acid) and disrupts bacterial adhesion to gastric epithelium; (2) cytoprotective — increases mucus secretion and prostaglandin E2 in gastric mucosa, protecting against acid damage; (3) anti-inflammatory — inhibits NF-κB and reduces inflammatory cytokines in gastric tissue; (4) lipid modulation — triterpenic acids inhibit cholesterol absorption and hepatic cholesterol synthesis (mechanism similar to plant sterols). The H. pylori mechanism is notable: mastic gum doesn't kill H. pylori like antibiotics; it disrupts its survival mechanisms (urease, adhesion), which may explain the 30% clearance rate.

OPTIMAL DOSAGE

Look for: "Chios mastic gum" or PDO-certified origin; whole resin tears or powder; 500-1,000mg per serving
Avoid: Non-Chios origin mastic; products not specifying geographic origin; very low doses (<250mg)
Minimum effective dose: 1g/day (3 weeks minimum)
Third-party tested brands: Mastika (Chios), Jarrow Formulas (Mastic Gum), NOW Foods

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

No critical interactions identified.

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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