Marshmallow mucilage is a mixture of polysaccharides (galacturonorhamnans, glucans, arabinogalactans) that: (1) form a viscous bioadhesive gel that coats mucous membranes — this PHYSICAL barrier protects tissue from acid, enzymes, and irritants (the mechanism is primarily MECHANICAL, not pharmacological); (2) stimulate epithelial cell proliferation — promoting mucosal repair; (3) activate macrophages — mild immune modulation; (4) inhibit mucociliary transport rate — reducing cough reflex by coating irritated sensory nerve endings in the pharynx. The cold-water extraction is essential because heat denatures the polysaccharide gel structure.
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.