Is L-Histidine safe to take daily?

L-Histidine is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

L-Histidine

MODERATE EVIDENCEAmino AcidLast updated

AVELOR SUMMARY

L-histidine is a conditionally essential amino acid and precursor to histamine (via histidine decarboxylase). Carnosine (beta-alanine + histidine) is the intracellular pH buffer in muscle. L-histidine supplementation (4g/day) improved hemoglobin in CKD patients (histidine is often deficient in renal disease). Also: zinc absorption enhancer (histidine chelates zinc for transport). Not commonly supplemented alone — usually obtained from carnosine or dietary protein. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

Scan a supplement containing L-Histidine

RELATED RESEARCH

5-HTP5-HTP (5-hydroxytryptophan) is an amino acid naturally produced in the body from

Acetyl-L-CarnitineMeta-analysis of 21 double-blind RCTs found significant cognitive improvement in MCI and early Alzhe

L-ArginineMeta-analysis of 11 RCTs: arginine reduced systolic BP by 5.39 mmHg and diastolic by 2.66 mmHg at do

BCAAs / EAAs

Scan Your L-Histidine Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 834 Ingredients Browse All 20 Conditions