What is the recommended dose of Jiaogulan?

- **Look for:** Standardized to gypenosides (XLIX or total gypenoside percentage specified); Gynostemma pentaphyllum species; 450mg+ per serving - **Avoid:** Non-standardized products (gypenoside c...

Is Jiaogulan safe to take daily?

Jiaogulan is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Jiaogulan

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Jiaogulan is called the "immortality herb" in southern China, where it was noted that regions with high jiaogulan tea consumption had unusual longevity. It contains over 100 dammarane-type saponins (gypenosides), many structurally identical to ginsenosides in Panax ginseng. Our research shows emerging evidence for AMPK activation, blood sugar reduction, and lipid management. A 2010 RCT found 6g/day tea reduced fasting glucose by 5.3 mmol/L in newly diagnosed type 2 diabetics — a dramatic effect. However, the evidence base is thin (mostly small Chinese studies) and the gypenoside profile varies enormously between products.

WHAT IT DOES

Gypenosides activate AMPK — the master metabolic sensor that responds to low cellular energy. AMPK activation: (1) increases glucose uptake in muscle cells (independent of insulin); (2) inhibits hepatic gluconeogenesis (reduces liver glucose output); (3) stimulates fatty acid oxidation; (4) inhibits lipogenesis. This is pharmacologically similar to metformin's mechanism, which is why the blood sugar reduction is significant. Additional mechanisms include NO-mediated vasodilation, SOD upregulation (antioxidant), and NF-κB suppression (anti-inflammatory).

OPTIMAL DOSAGE

Look for: Standardized to gypenosides (XLIX or total gypenoside percentage specified); Gynostemma pentaphyllum species; 450mg+ per serving
Avoid: Non-standardized products (gypenoside content varies enormously); token doses in adaptogen blends; products not identifying species
Minimum effective dose: 450mg standardized extract or 6g dried herb tea
Third-party tested brands: Limited availability in US; Maypro (ActivAMP — branded extract with AMPK data)

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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