Is Evodiamine safe to take daily?

Evodiamine is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Evodiamine

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Evodiamine is a thermogenic compound from the Chinese herb Evodia that activates TRPV1 (vanilloid receptor — same as capsaicin) to increase core body temperature and energy expenditure. In vitro data shows fat cell apoptosis and anti-obesity effects. ZERO human clinical trials exist. Sold in fat-burner supplements but no established human dose. Our assessment: promising mechanism, zero human evidence. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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