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Additive liver risk
Monitor liver enzymes. Avoid with existing liver issues.
Reduces drug effectiveness
Avoid during tamoxifen therapy.
Increases bleeding risk
Monitor INR. Use with extreme caution.
Increases bleeding risk
Avoid combination.
Increases drug levels
Monitor tacrolimus levels closely.
Possible INR increase
Monitor INR if combining.
Reduces drug levels
Avoid or monitor drug levels.
Alters drug levels
Monitor drug effects.
Alters drug levels
Monitor drug effects.
Increases drug absorption
Monitor.
Increases drug absorption
Monitor for increased side effects.
May cause iron deficiency
Monitor iron if taking high-dose turmeric chronically.
Increases drug absorption
Monitor.
Increases drug levels
Monitor for statin side effects.
Additive BP reduction
Monitor BP.
Additive glucose reduction
Monitor blood glucose.
△ Curcumin is an interaction minefield — it affects CYP1A2, CYP2D6, CYP3A4, P-glycoprotein, and BCRP transporters. Adding piperine amplifies these interactions.
Not Prohibited.
Based on independent third-party laboratory analysis
Category pass rate: 76% pass rate — 24% of products fail. Additionally, 47% of Bangladesh-sourced turmeric contains intentionally-added lead.
Contamination risk: HIGH. 47% of Bangladesh turmeric has intentionally-added lead (lead chromate) to enhance yellow color. Always check country of origin.
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 5, 2026
Not medical advice. Based on published clinical research and systematic reviews.
Safety
Moderate interactions. Monitoring, timing separation, or dose adjustment may be required.
Warfarin and other anticoagulants
SourceClinical pharmacology
Aspirin and NSAIDs
SourceClinical consensus
Diabetes medications (metformin, sulfonylureas)
SourcePMID: 34956436
CYP3A4 substrates
SourceIn vitro data
Tacrolimus or cyclosporine
SourceTheoretical
Stop 2 weeks before surgery
High-dose antiplatelet effect.
Educational information only. This is not medical advice. These statements have not been evaluated by the FDA. Talk to your prescriber before starting, stopping, or combining any supplement with prescription medication.