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Reviewed by the Scan Dose Research Team and Clinical Advisory Board

Boron

MODERATE EVIDENCEMineralLast updated April 2026

SCAN DOSE SUMMARY

Boron is an ultra-trace mineral with emerging evidence for bone health, testosterone support, and cognitive function. Our research shows it influences calcium, magnesium, and vitamin D metabolism, and may modestly increase free testosterone by reducing SHBG — but the evidence base is thin and mostly observational. It's cheap, safe at low doses, and likely beneficial for people with inadequate dietary intake.

EVIDENCE GRADES

Bone mineral density (postmenopausal women)Moderate — observational + interventional
B-
Testosterone (free testosterone via SHBG reduction)Limited — small studies (PMID: 21129941)
C+
Cognitive functionDeprivation studies show impairment; supplementation data weak
C
Arthritis / joint healthEpidemiological associations + limited trials
C
Vitamin D metabolismMay increase 25(OH)D levels when boron-depleted
C+

WHAT IT DOES

Boron influences the metabolism of calcium, magnesium, phosphorus, and vitamin D. It inhibits the hydroxylase enzymes that deactivate 17β-estradiol and vitamin D, effectively extending their half-lives. Boron also reduces SHBG (sex hormone-binding globulin), which increases free testosterone — though the magnitude is modest.

Dietary boron comes from fruits, vegetables, nuts, and legumes. Average dietary intake is 1-3mg/day. The proposed adequate intake is 1-13mg/day depending on the source.

OPTIMAL DOSAGE

  • General support: 3-6mg/day
  • Bone health: 3-6mg/day (combined with calcium, D, and magnesium)
  • Testosterone support: 6-10mg/day
  • Upper tolerable limit: 20mg/day (adults)
Scan a supplement containing Boron

DRUG INTERACTIONS

Estrogen therapy / HRTModerate

Boron may increase estradiol levels; additive estrogenic effects

SAFETY PROFILE

Drug Interactions

Side Effects

  • No adverse effects at doses ≤20mg/day
  • Toxicity (nausea, vomiting, diarrhea) at >20mg/day
  • Severe toxicity at gram-level doses (not achievable through supplementation)

Pregnancy & Lactation

  • No safety data for supplemental boron during pregnancy. Dietary boron from foods is safe.

WADA Status

Not Prohibited

HOW SCAN DOSE SCORES THIS

3-6mg in a multivitamin or bone health formula: score normally
>10mg standalone: note that evidence is thin at higher doses
Estrogen/HRT users: flag additive estrogenic effect
Often underdosed or absent in multivitamins — Dose AI can flag this as a gap in bone health formulas

CLINICAL REFERENCES

1.

Naghii MR et al. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines.

PMID: 21129941

2.

Nielsen FH. Studies on the relationship between boron and magnesium.

PMID: 8112856

3.

Penland JG. Dietary boron, brain function, and cognitive performance.

PMID: 7889887

RELATED RESEARCH

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Calcium D-Glucarate
CalciumCalcium carbonate
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Scan Your Boron SupplementBrowse all ingredients

Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

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