Is Ashitaba safe to take daily?

Ashitaba is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Ashitaba

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Japanese longevity herb from Hachijō Island. Contains 4,4'-dimethoxychalcone (DMC) — the compound identified in a 2019 Nature Medicine paper as activating autophagy and extending lifespan in yeast, worms, and flies. DMC is the ONLY chalcone shown to activate TFEB (transcription factor EB — master regulator of autophagy). Also contains prenylated chalcones with anti-inflammatory and anti-diabetic activity. Limited human data but the autophagy mechanism is validated in multiple model organisms. Dose: 500-1,500mg/day dried leaf/stem. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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